The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis
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چکیده
منابع مشابه
The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis
BACKGROUND Arginine is an amino acid that serves as a substrate for the enzymes nitric oxide synthase (NOS) and arginase, leading to synthesis of NO and ornithine, respectively. As such, arginine has the potential to influence diverse fundamental processes in the lung. METHODS We used mice deficient in cationic amino acid transporter (CAT) 2 in models of allergic airway inflammation and pulmo...
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Arginine is an amino acid that serves as a substrate for nitric oxide synthase and arginase. As such, arginine has the potential to influence diverse fundamental processes in the lung. Here we report that the arginine transport protein, cationic amino acid transporter (CAT)2, has a critical role in regulating lung inflammatory responses. Analysis of CAT2-deficient mice revealed spontaneous infl...
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ژورنال
عنوان ژورنال: Respiratory Research
سال: 2010
ISSN: 1465-993X
DOI: 10.1186/1465-9921-11-87